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      [b]What is the mechanism of action of colchicine quizlet?[/b] What is the mechanism of action of colchicine ? Colchicine binds to tubulin inhibiting its polymerizatio and preventing the formation of microtubules. This disrupts cellular functions, such as the mobility of granulocytes, thus decreasing their migration into the affected area.
      [b]How long does it take for colchicine to leave your system?[/b] The initial response to oral colchicine occurs between 12 to 24 hours and the peak response is expected within 48 to 72 hours. Extracorporeal Elimination: Colchicine is not removed by haemodialysis. INDICATIONS: Treatment of acute gout.
      [b]What type of medication is colchicine?[/b] Colchicine is in a class of medications called anti-gout agents. It works by stopping the natural processes that cause swelling and other symptoms of gout and FMF.
      [b]What is the main cause of gout?[/b] Causes. Gout is caused initially by an excess of uric acid in the blood, or hyperuricemia. Uric acid is produced in the body during the breakdown of purines – chemical compounds that are found in high amounts in certain foods such as meat, poultry, and seafood.
      [b]What is the medication of choice for an initial acute attack of gout?[/b] NSAIDs are the drugs of choice in most patients with acute gout who do not have underlying health problems. Although indomethacin is the NSAID traditionally chosen for acute gout, most of the other NSAIDs can be used as well. Select an agent with a quick onset of action.
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